Why did Itachi wipe out the entire Uchiha clan?

Itachi killed his clan because he was under the impression they were going to overthrow the village. Danzo struck a deal with Itachi that allowed Sasuke to be spared, so long as Itachi made it seem that he simply went rogue to test his power.

Why was Itachi not loyal to his clan?

Itachi didn’t support the Uchiha because their plan involved killing and violence, which he was against. He agreed to massecre his clan because he didn’t want them to kill many people in the hostile take over, and he wanted all the people of the leaf and the Uchiha to live in peace.

Did Itachi ever regret killing his clan?

No. Itachi never regretted about that. The only regret he had was that he never filled Sasuke in any of his matters and also made Sasuke to choose the wrong path.

Did Itachi really kill Shisui?

Itachi had the Mangekyo when he killed his clan and he had to kill Shisui to obtain it. So, no, Danzou did not kill Shisui. The clane would have noticed his eye was missing when they found his body if Danzou had killed him and taken it.

Why does Itachi leave Sasuke?

Itachi could have easily said that he saved himself and Sasuke and started a new life elsewhere, determining to end the cycle of hatred with them. Sasuke could have been happy with his brother, even though losing the clan would still be devastating. Instead, Itachi did what he did and it made Sasuke into a vengeful monster .

Why does Itachi wanted to take Sasuke,s eyes?

To push Sasuke in this direction, Itachi withheld the true reason for his actions and instead took on the persona of a man who had no love for his younger brother. Per the persona, Itachi cared about Sasuke only because of the eyes that he could take to gain Eternal Mangekyō Sharingan.

Why does Itachi die?

Itachi died in his sight with Sasuke from an unkown illness, he was using medicine to prolong his life before the fight.