Can I take spironolactone with estrogen?

by taking estrogen with an androgen blocker medicine (spironolactone) that lowers blood pressure. If you cannot take spironolactone, you can make other changes to reduce your risk. This includes other types of medicine, exercise, not smoking and changes to your diet.

How quickly does spironolactone work MTF?

The clinical benefits of spironolactone as a diuretic are typically not seen until 2–3 days after dosing begins. Likewise, the maximal antihypertensive effect may not be seen for 2–3 weeks.

Does spironolactone make you feminine?

Feminizing hormone therapy often involves taking estrogen and anti-androgen hormones, such as estradiol or spironolactone. By taking these hormones, you may be able to achieve more traditionally feminine characteristics, including breast growth, body fat redistribution, and less facial hair.

Why is spironolactone used in transgender?

Typically, you’ll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. This blocks male sex hormone (androgen) receptors and can suppress testosterone production.

Can I take estrogen as a woman?

You can take estrogen in the form of a pill, patch, gel, vaginal cream, or slow-releasing suppository or ring that you place in your vagina. If you experience only vaginal symptoms related to menopause, estrogen in a low-dose vaginal cream, tablet or ring is usually a better choice than an oral pill or a skin patch.

Can you take Spiro and Accutane together?

No interactions were found between Accutane and spironolactone. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What happens when you take estrogen MTF?

The first changes you will probably notice are that your skin will become a bit drier and thinner. Your pores will become smaller and there will be less oil production. You may become more prone to bruising or cuts and in the first few weeks you’ll notice that the odors of your sweat and urine will change.

What happens if you take estrogen as a man?

Estrogen may stimulate breast tissue growth. Men with too much estrogen may develop gynecomastia, a condition which leads to larger breasts. Erectile dysfunction (ED). Men with high levels of estrogen may have difficulty getting or maintaining an erection.

How long does Spiro take to work?

Spironolactone is started at doses of 25-100mg per day and increased every 6 to 8 weeks until a dose that improves the acne is reached. There are many variations to this regime. Improvement in acne can take 3 to 6 months to be seen.

What should estradiol levels be for MTF?

For transgender women, the Endocrine Society guidelines define the target range of estradiol as 100–200 pg/mL (367–734 pmol/L)1; as many providers in our practice do not titrate therapy when estradiol levels are above 90 pg/mL (330 pmol/L), the range of 90–200 pg/mL (330–734 pmol/L) was used to define effective …

What hormones do transgender females take?

The most common estrogens used in transgender women include estradiol, which is the predominant natural estrogen in women, and estradiol esters such as estradiol valerate and estradiol cypionate, which are prodrugs of estradiol.

Is 1 mg of estradiol enough?

Dose — “Standard” doses of estrogen given daily, such as 17-beta estradiol (oral 1 mg/day or transdermal 0.05 mg/day) are adequate for symptom relief in the majority of women [3-5].

What is the best hormone regime for transgender women?

Hormone regimes for transgender women (male to women, MTF) 1. Anti-androgen. Spironolactone 100 – 200 mg/day (up to 400 mg) Cyproterone acetatea 50–100mg/day; GnRH agonists 3.75 mg subcutaneous monthly 2. Oral estrogen. Oral conjugated estrogens 2.5–7.5mg/day; Oral 17-beta estradiol 2–6mg/day 3.

What is the use of estradiol in trans women?

Its sole use in trans patients is to reduce the effect of testosterone, and also testosterone levels, a job that estradiol would do if a suitable estradiol-only regimen were used instead.

Does Spiro affect breast development in trans women?

Finally, Spiro use is associated with poor breast development in trans women. A preliminary study showed that patients using Spiro instead of another antiandrogen (such as Cyproterone) had significantly more dissatisfaction with breast development. (13) At this point, the causation is uncertain.

Is cross-sex hormone therapy medically necessary for transgender individuals?

The number of transgender individuals seeking cross-sex hormone therapy has risen over the years (6). The administration of exogenous virilizing hormones is considered medically necessary for many transgender individuals (7).