Why diclofenac is contraindicated in asthma?

… NSAIDs are generally considered to be contraindicated in children with asthma because they may trigger bronchospasm in sensitive children. [150,151] This presents particular problems in the pediatric population because the incidence of childhood asthma is high (over 10\% in many countries).

How do NSAIDs cause bronchoconstriction?

NSAID-induced reactions appear to be caused by the inhibition of cyclooxygenase-1 (Cox-1); this in turn activates the lipoxygenase pathway, which eventually increases the release of cysteinyl leukotrienes (Cys-LTs) that induces bronchospasm and nasal obstruction.

What is a main contraindication of NSAIDs?

According to the package insert, NSAIDs are contraindicated in patients: With NSAID hypersensitivity or salicylate hypersensitivity, as well as in patients who have experienced an allergic reaction (urticaria, asthma, etc.) after taking NSAIDs.

Why aspirin is not given in asthma?

Some people with asthma cannot take aspirin or NSAIDs because of what’s known as Samter’s triad — a combination of asthma, aspirin sensitivity, and nasal polyps. Nasal polyps are small growths that form inside the nasal cavity.

Why does ibuprofen worsen asthma?

Ibuprofen can also worsen asthma symptoms by causing the airways to narrow in a condition known as bronchospasm. Aspirin-induced asthma is another recognized condition, which is believed can occur with the use of other NSAIDs as well. Around 20 percent of adults with asthma will have aspirin-induced asthma.

Why NSAIDs are contraindicated in hypertension?

They are often used to relieve pain or reduce inflammation from conditions such as arthritis. However, NSAIDs can make your body retain fluid and decrease the function of your kidneys. This may cause your blood pressure to rise even higher, putting greater stress on your heart and kidneys.

How do NSAIDs effect asthma?

Aspirin and other NSAIDs can induce bronchospasm and, in rare cases, this reaction can lead to death in aspirin-sensitive asthmatics. This reaction is generally referred to as aspirin-induced asthma. The reported incidence varies widely affecting between 8\% and 20\% of adult asthmatics.

How can NSAIDs trigger asthma?

Paradoxically, NSAIDs, including aspirin, possibly cause asthma exacerbations, particularly in patients allergic to these drugs. Aspirin/NSAIDs inhibit cyclooxygenase (COX) and reduce prostaglandin synthesis, thereby reducing fever and relieving pain and inflammation.

Why are NSAIDs contraindicated with anticoagulants?

NSAIDs can induce gastrointestinal bleeding, which is likely to be more severe if warfarin is also given. Conclusions: The combined use of warfarin and NSAIDs is generally discouraged because of the increased risk of bleeding in these patients.

Why are NSAIDs contraindicated in hypertension?

What anti inflammatories are safe for asthmatics?

Unlike aspirin and other NSAIDS, acetaminophen seems to be safer for people with asthma. Acetaminophen is also less likely to cause gastrointestinal problems than NSAIDs. It is safe for women who are pregnant and nursing.

What drugs should be avoided in asthma?

Medicines Can Trigger Asthma

• Aspirin.
• Non-steroidal anti-inflammatory drugs, like ibuprofen (Motrin® or Advil®) and naproxen (Aleve® or Naprosyn®)
• Beta-blockers, which are usually used for heart conditions, high blood pressure and migraines.